Reactivation-Dependent Amnesia: Disrupting Memory Reconsolidation as a Novel Approach for the Treatment of Maladaptive Memory Disorders

Abstract

The persistence of memories reflects a dynamic, rather than a stable, process. The reactivation of a previously learned memory, for example by re-exposure to a conditioned stimulus, renders it labile, such that the concomitant administration of a variety of amnestic agents results in a reduced ability subsequently to retrieve that memory. This reactivation-dependent amnesia suggests that memories may undergo cycles of reactivation followed by a process of what has been called ``reconsolidation{''}. This review will discuss several of the central features of memory reconsolidation, taking a translational view of the potential of disrupting reconsolidation as a treatment strategy for maladaptive memory disorders such as post-traumatic stress and drug addiction.