NMR has proven to be an invaluable technique for identifying and characterizing ligand interactions with biomolecules. NMR-based detection of ligand binding to protein targets is described. Specifically, the use of the WaterLOGSY NMR experiment to screen mixtures of compounds from a fragment library for binding to influenza H5 hemagglutinin is detailed.
CITATION STYLE
Ramirez, B. E., Antanasijevic, A., & Caffrey, M. (2014). Ligand screening using NMR. Methods in Molecular Biology, 1140, 305–313. https://doi.org/10.1007/978-1-4939-0354-2_22
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