Model of the activity of hippocampal neurons based on the theory of selective desensitization

Abstract

The integration of different kinds of information is thought to be a key function of the hippocampus. On the basis of a computational theory, we hypothesize that the hippocampus performs information integration using selective desensitization of CA3 neurons, and construct a model of the hippocampal trisynaptic network on the basis of this hypothesis. This model can reproduce the results of a physiological experiment in which rat hippocampal place cells in various environments were recorded, whereas the conventional layered model cannot. This result, together with some other physiological evidence, supports our hypothesis. © 2009 Springer Berlin Heidelberg.