Improved stability of emulsions in preparation of uniform small-sized konjac glucomanna (KGM) microspheres with epoxy-based polymer membrane by premix membrane emulsification

7Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Uniform small-sized (<10 μm) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa·s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 μm, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena.

Cite

CITATION STYLE

APA

Mi, Y., Li, J., Zhou, W., Zhang, R., Ma, G., & Su, Z. (2016). Improved stability of emulsions in preparation of uniform small-sized konjac glucomanna (KGM) microspheres with epoxy-based polymer membrane by premix membrane emulsification. Polymers, 8(3). https://doi.org/10.3390/polym8030053

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free