Recent work in neuroscience supports the idea that variability in brain function is necessary for optimal brain responsivity to a changing environment. In this review, we discuss a series of functional magnetic resonance imaging (fMRI) studies in younger and older adults to assess age-related differences in variability of the fMRI signal. This work shows that moment-to-moment brain signal variability represents an important "signal" within what is typically considered measurement-related "noise" in fMRI. This accumulation of evidence suggests that moving beyond the mean will provide a complementary window into aging-related neural processes. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Grady, C. L., & Garrett, D. D. (2014). Understanding variability in the BOLD signal and why it matters for aging. Brain Imaging and Behavior. Springer New York LLC. https://doi.org/10.1007/s11682-013-9253-0
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