Gene Electrotransfer to Tumor

Abstract

In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models. For cancer therapy, direct delivery to the tumor may be used to generate a direct antitumor effect or delivery to other sites may be performed to produce cancer vaccines. Many of the preclinical therapies tested have demonstrated therapeutic efficacy against several tumor types. Some of these therapies have advanced to cancer clinical trials. This chapter discusses both preclinically tested therapies with clinical potential and current cancer human trials.