Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments

252Citations
Citations of this article
67Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Although recent studies have indicated that the major histocompatibility complex-like, β2-microglobulin-associated CD1 molecules might function to present a novel chemical class of antigens, lipids and glycolipids, to α/β T cells, little is known about the T cell subsets that interact with CD1. A subset of CD1d-autoreactive, natural killer (NK)1.1 receptor-expressing α/β T cells has recently been identified. These cells, which include both CD4- CD8- and CD4+ T cells, preferentially use an invariant Vα14-Jα281 T cell receptor (TCR) α chain paired with a Vβ8 TCR β chain in mice, or the homologous Vα24-JαQ/Vβ11 in humans. This cell subset can explosively release key cytokines such as interleukin (IL)-4 and interferon (IFN)-γ upon TCR engagement and may regulate a variety of infectious and autoimmune conditions. Here, we report the existence of a second subset of CD1d- restricted CD4+ T cells that do not express the NK1.1 receptor or the Vα14 TCR. Like the Vα14+ NK1.1+ T cells, these T cells exhibit a high frequency of autoreactivity to CD1d, use a restricted albeit distinct set of TCR gene families, and contribute to the early burst of IL-4 and IFN-γ induced by intravenous injection of anti-CD3. However, the Vα14+ NK1.1+ and Vα14- NK1.1- T cells differ markedly in their requirements for self-antigen presentation. Antigen presentation to the Vα14+ NK1.1+ cells requires endosomal targeting of CD1d through a tail-encoded tyrosine-based motif, whereas antigen presentation to the Vα14- NK1.1- cells does not. These experiments suggest the existence of two phenotypically different subsets of CD1d-restricted T cells that survey self-antigens loaded in distinct cellular compartments.

References Powered by Scopus

CD1d-restricted and TCR-mediated activation of V(α)14 NKT cells by glycosylceramides

2255Citations
N/AReaders
Get full text

Mouse CD1-specific NK1 T cells: Development, specificity, and function

1223Citations
N/AReaders
Get full text

Requirement for V(α)14 NKT cells in IL-12-mediated rejection of tumors

1179Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The biology of NKT cells

1932Citations
N/AReaders
Get full text

Antigen presentation and T cell stimulation by dendritic cells

1554Citations
N/AReaders
Get full text

NKT cells: What's in a name?

1069Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chiu, Y. H., Jayawardena, J., Weiss, A., Lee, D., Park, S. H., Dautry-Varsat, A., & Bendelac, A. (1999). Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. Journal of Experimental Medicine, 189(1), 103–110. https://doi.org/10.1084/jem.189.1.103

Readers over time

‘09‘10‘11‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘25036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 30

53%

Researcher 16

28%

Professor / Associate Prof. 10

18%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 33

55%

Medicine and Dentistry 13

22%

Immunology and Microbiology 8

13%

Biochemistry, Genetics and Molecular Bi... 6

10%

Save time finding and organizing research with Mendeley

Sign up for free
0