Abstract
The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.
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Tanaka, R., Ono, T., Sato, S., Nakada, T., Koizumi, F., Hasegawa, K., … Nakayama, E. (2004). Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity. Microbiology and Immunology, 48(4), 339–345. https://doi.org/10.1111/j.1348-0421.2004.tb03515.x
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