Adrenal diseases

Abstract

The adrenal cortex play key roles in regulating intermediary metabolism, fluid and electrolyte balance, and the response to stress. Molecular analyses of specific disorders resulting from either the diminished or enhanced production/action of corticos-teroids have led to the identification of a number of genes that play key roles in adrenal function and corticosteroid action. These genes provide potential targets for novel therapies that may revolutionize our approaches to these rare adrenal diseases. In addition, understanding the molecular causes of these diseases has provided important insights into basic adrenal functions that may translate into improved therapy of more common disorders such as hypertension and obesity. © 2006 Humana Press Inc.