A marine isonitrile produced by Indonesian marine sponge of Petrosia sp. as an inhibitor of the human pancreatic cancer cells

Abstract

The study of search the bioactive compound from Indonesian Marine Sponge Petrosia sp. has been conducted on February 2019. The bioactive compound isolated based on bioassay-guided separation with several steps of chromatography. The compound known as C16H25NS determined by lCmS-ESI with molecular weight [M+H]+263.42m/z. The FTIR data showed that the functionality as hydrocarbon skeletone of alkane and isonitrile at 2982.58 cm-1 and 2115 cm-1, respectively. Furthermore, the NMR data confirm that the active compound knowns as 4-amorphene-10- isothiocyanate. The cytotoxic data indicate that the bioactive compound has activity against Panc-1 cell [IC50 = 0.1 μg / mL].The secondary metabolite from Indonesian marine sponge of Petrosia sp. has potential activity against human pancreatic cancer cells.