Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

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Abstract

Objective: Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.Method: In this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.Results: All four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.Conclusion: This case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations. © 2013 Eryi{dotless}lmaz et al.; licensee BioMed Central Ltd.

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Eryilmaz, G., Hizli Sayar, G., Ozten, E., Gögcegöz Gül, I., & Karamustafalioǧlu, O. (2013). Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia. Annals of General Psychiatry, 12(1). https://doi.org/10.1186/1744-859X-12-40

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