Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice

92Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

Flavonoids have been demonstrated to provide health benefits in humans. Baicalein (5,6,7-trihydroxyflavone) is a phenolic flavonoid compound derived mainly from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used in oriental medicine. Baicalein is widely used in Korean and Chinese herbal medicines as anti-inflammatory and anticancer therapy. However, the molecular mechanisms of its activity remain poorly understood and warrant further investigation. This study was performed to investigate the anticancer effect of baicalein on HCT116 human colon cancer cells and the tumor preventing capacity of baicalein on colitis-associated cancer in mice. In in vivo experiments, we induced colon tumors in mice by azoxymethane (AOM) and dextran sulfate sodium (DSS) and evaluated the effects of baicalein on tumor growth. Baicalein treatment on HCT116 cells resulted in a concentration-dependent inhibition of cell growth and induction of apoptotic cell death. The induction of apoptosis was determined by morphological changes and cleavage of poly(ADP-ribose) polymerase. Baicalein also suppressed the activation of NF-κB through PPARγ activation. These results indicate that the anti-inflammatory effects of baicalein may be mediated through PPARγ activation. Finally, administration with baicalein significantly decreased the incidence of tumor formation with inflammation. Our findings suggest that baicalein is one of the candidates for the prevention of inflammation-associated colon carcinogenesis.

References Powered by Scopus

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences

2589Citations
N/AReaders
Get full text

New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

793Citations
N/AReaders
Get full text

PPARs and molecular mechanisms of transrepression

473Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The fascinating effects of baicalein on cancer: A review

202Citations
N/AReaders
Get full text

Anticancer properties of baicalein: a review

119Citations
N/AReaders
Get full text

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice

96Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kim, D. H., Hossain, M. A., Kang, Y. J., Jang, J. Y., Lee, Y. J., Im, E., … Kim, N. D. (2013). Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice. International Journal of Oncology, 43(5), 1652–1658. https://doi.org/10.3892/ijo.2013.2086

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

70%

Professor / Associate Prof. 3

15%

Lecturer / Post doc 2

10%

Researcher 1

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

39%

Biochemistry, Genetics and Molecular Bi... 5

28%

Chemistry 4

22%

Neuroscience 2

11%

Save time finding and organizing research with Mendeley

Sign up for free