Miscellaneous manifestations of Behçet's disease

Abstract

Behçet's disease is infrequently associated with hematological, auditory, renal, and urological abnormalities. The most significant hematological alteration is the myelodysplastic syndrome, usually linked to trisomy 8. The development of BD-like symptoms in patients with chronic myelogenous leukemia has also been reported. Hearing loss, mostly of the sensorineural type seems to be more common than generally realized. It is usually indolent in nature and may be uni or bilateral. Renal involvement is rare as contrasted to the ANCA-associated vasculitides. However, it may be seen in the form of AA amyloidosis or as glomerulonephritis. Renal vascular disease or interstitial involvement may occasionally be observed. Successful transplantation in end-stage renal disease has been reported. Primary bladder involvement due to vasculitis and secondary involvement due to neuro-Behçet are examples of urological manifestations. They usually present with hematuria or voiding difficulties. Epididymitis and impotence are also seen. © 2010 Springer Science+Business Media, LLC.