Regulation of Epithelial-Mesenchymal Transition by Transcriptional Factors in Cervical Carcinoma

Abstract

Cervical carcinoma is a most prevalent cancer in women worldwide. The metastasis is one of the major issues for late-stage cervical carcinoma in patients. Epithelial-mesenchymal transition (EMT) has been implicated in cervical carcinoma progression and metastasis. During EMT, cervical carcinoma cells lose epithelial features and gain a mesenchymal phenotype. The EMT has been identified to be regulated by key transcription factors including Snail, Zeb, and Twist. In this review, we will discuss our current understanding of how these key transcription factors play important roles in EMT program of cervical carcinoma cells.