Hollow and non-hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage-like cells in vitro, improve anti-cancer immunity, CD4(+) and CD8(+) T cell populations in splenocytes of mice in vivo.
CITATION STYLE
Wang, X., Li, X., Ito, A., Yoshiyuki, K., Sogo, Y., Watanabe, Y., … Tsuji, N. M. (2016). Silica Nanospheres: Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo (Small 26/2016). Small, 12(26), 3602–3602. https://doi.org/10.1002/smll.201670129
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