Innovative platforms for haploidentical stem cell transplantation: The role of unmanipulated donor graft

Abstract

We exploited the dual positive effects of rapamycin to prevent GvHD and control malignant cells upon infusion of unmanipulated grafts from family haploidentical donors to patients affected by advanced hematological malignancies. Preliminary results on 45 patients show the feasibility of this platform with an appreciable low rate of GvHD. © Ivyspring International Publisher.