Treatment resistant de novo Epidermal Growth Factor Receptor (EGFR)-mutated Small Cell Lung Cancer

Abstract

Epidermal growth factor receptor (EGFR) mutations are a rare occurrence in small cell lung cancer (SCLC), existing either de novo or in cases of transformed EGFR-mutant (mt) adenocarcinoma. In the de novo setting, treatment outcomes and response to EGFR-tyrosine kinase inhibitors is unclear. We report a rare case of a female patient, who had never smoked, with de novo EGFR-mt SCLC and describe treatment outcomes to both platinum-based chemotherapy and erlotinib. Considering the rarity of EGFR mutations reported in SCLC and the unclear role of EGFR-tyrosine kinase inhibitors in this setting, a review of the literature will also be presented.