Modeling of voltage imaging for the study of action potential propagation

Abstract

Voltage imaging allows to visualize the propagation of the action potential while it propagates in cardiac tissue. In our experiment we acquire a stack of voltage images, using a fluorescence microscope. In this work we focus on the development of a model of the signal and on the estimation of its parameters. We assumed the signal can be represented as the sum of two exponential functions, starting from the instant of activation of the cell. Results indicate the model is able to adequately describe the shape of the waveform, despite the high noise level in the original images.