Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity: I. taxonomy of the producing organisms, fermentation and antimicrobial activity

Abstract

The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity. © 1991, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.