Synthesis of some new thiazolidinone compounds derived from schiff bases compounds and evaluation of their laser and biological efficacy

Abstract

In this work 6-fuloro-2-aminobenzothazol compound (R1) have been prepared from the reaction of aniline with appropriate potassium thiocyanate in presence cooled glacial acetic acid in such a way to temperature not exceeded above room temperature, Solution of 1.6ml of bromine in 6ml of glacial acetic acid, the reaction 6-fuloro-2-aminobenzothazol of with Hydrazine hydrate 6-fluoro-2-hydrazineylbenzo thiazole yielded compounds (R2). The research included synthesis of schiff base from the reaction of with appropriate aromatic aldehydes in presence of glacial acetic acidyieldeds compounds (R3-R7) 2-(2-benzylidenehydrazineyl)-6-chlorobenzo thiazole, and synthesis of thiazolidinone from the reaction of thioglycolic acid with schiff base,yieldeds compounds (R8-R12) chloro-N-(5-phenyl-2,5-dihydro-tetrazol-1-yl) benzo thiazol-2. The prepared compounds have been characterized by melting points and some physical properties besides the FT-IR, H-NMR spectra and quantitative analysis of elements (C.H.N.). The purity for these compounds was checked by TLC. The study is showed biological activity for chemical compounds, at three concentrations (10-2,10-3,10-4) mg/ml The minimum inhibitory concentration [MIC] have been determined with the reference of stander drugs the results showed that the thiazolidinone derivatives are better than growth of both types of bacteria gram-positive and gram-negative compared to drug, and evaluation of laser efficacy.