TOLNAFTATE MICROSPONGES EMBEDDED BIOCOMPATIBLE GELS FOR CONTROLLED AND EFFECTIVE ANTIDERMATOPHYTIC ACTIVITY

Abstract

The aim of this investigation was to develop potentially efficient Tolnaftate Microsponges embedded gels for effective management of dermatophytosis, which has been highly ignored skin ailment in the current era. Immunosuppressant and patients suffering from severe diseases are highly prone to dermatophytosis. Herein Tolnaftate microsponges were prepared through quassi-emulsion solvent diffusion technique applying biocompatible polymers Eudragit RL100 and Eudragit RS100. Formulated Microsponges were embedded in Carbopol 934 and HPMC to attain controlled topically effective formulation and their physical parameters like viscosity, pH, spreadibility, the in-vitro drug release kinetics were evaluated. Drug-excipient compatibility was performed by FTIR and TGA. FESEM analysis revealed micro size microsponges with numerous pores present over their surface. Several in-vitro release kinetics models were applied, and the formulated gels followed Korsmeyer Peppas model. Antidermatophytic activity against Trichophyton mentagrophytes revealed a distinct zone of inhibition and showed the potential role for the management of dermatophytosis.