Statistische Physik und Thermodynamik

Abstract

Introduction: Binge eating behaviour is characterised by eating a large amount of food uncontrollably without purging. Appetite and satiety are influenced by complex central and gut-related hormonal systems which modulate the regulation of food intake. This study examined the possible alterations in glucagon-like peptide 1 (GLP-1) in individuals with binge eating behaviour. Methods: Binge eating questionnaires were distributed to healthy non-diabetic obese participants and they were categorised into binge eaters (score > 17) and non-binge eaters (score ≤ 17). A seven-pointprofile of plasma GLP-1 following an overnight 12 hour fast, before and after ingestion of a nutritionally complete meal (460 kcal) was done at time -15, 0, 15, 30, 60, 90, and 120 minutes. Appetite ratings including hunger and fullness were also obtained. Results: 44 binge eaters and 21 non-binge eaters participated. Both groups were of comparable age, 33 years (29-37.5) and body-mass index, 35.9 kg/m2 (33.2-38.8). There were 9 males in each group. None of these participants had impaired fasting glucose, 5 mmol/L (4.75-5.4).Fasting and post-meal changes in GLP-1 levels did not differ between the two groups but both groups had significant increase from time -15 to 30 min, 32 ± 13.5 to 45 ± 18.1 pmol/L (p = 0.000) among binge group and 35 ± 19.0 to 53 ± 20.0 pmol/L (p = 0.001) among non-binge group. The binge group showed lower increment in GLP-1 levels pre-meal (-15 to 0 min) in comparison to the non-binge group (2.6 ± 6.2 vs 8.8 ± 10.2 pmol/L respectively, p = 0.016. Hunger and fullness ratings did not differ between groups. Conclusion: The two groups demonstrated similar levels of GLP-1. However, the lower increase in pre-meal levels may indicate an early reduction of GLP-1 effect within the binge eaters. (Figure Presented).