Management of Linear IgA Disease in Adults

Abstract

Linear immunoglobulin A (IgA) disease is an acquired autoimmune blistering condition of the skin and mucous membranes, characterised by linear deposition of IgA along the dermoepidermal basement membrane zone. In adults, drug triggers should be considered and withdrawn if suspected. Dapsone is the systemic treatment of choice, but ineffective or poorly tolerated alternative treatments include sulphonamides, anti-inflammatory antimicrobials, systemic steroids or other immunosuppressives.