Purpose: To enhance the antimicrobial and antioxidant activities of benzoylaminoethanoic acid (BAEA) and nicotinamide (NA). Methods: Complexes of benzoylaminoethanoic acid (BAEA) and nicotinamide (NA) were prepared in a microwave oven. These metal complexes were evaluated by various techniques including 1H and 13C nuclear magnetic resonance spectrometry (NMR), infrared spectrometry (IR), ultraviolet-visible spectrometry (UV), mass spectrometry (MS), thermogravemetric analysis (TGA) and molar conductivity. The synthesized compounds were screened for both antibacterial and antifungal activities using disc diffusion technique. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method was used to assess the antioxidant activity of the complexes. Results: Based on the results of spectroscopic techniques and physicochemical characterization, these complexes have been named [Cu(NA)2(BAEA)Cl2], [Co(NA)2(BAEA)Cl2], and [Ni(NA)2](BAEA)Cl2], respectively. A model structure with a distorted octahedron was proposed based on the outcome of the magnetic, analytical and spectral analyses. Synthesized metal complexes were more effective and efficient than nicotinamide and benzoylaminoethanoic acid. Conclusion: Efficiently synthesized mixed metal complexes were prepared using a simple, eco-friendly rapid green chemistry methodology. The newly synthesized complexes have significant antimicrobial activities against the test bacterial and fungal strains.
CITATION STYLE
Shiekh, R. A., Said, M. A., Malik, M. A., & Hashmi, A. A. (2018). Antimicrobial and antioxidant studies of novel mixed-metal complexes of benzoyl-aminoethanoic acid-nicotinamide: Microwave-assisted green synthesis, spectroscopic characterization and molecular modeling. Tropical Journal of Pharmaceutical Research, 17(5), 865–874. https://doi.org/10.4314/tjpr.v17i5.17
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