Musashi1 (Msi1) is an evolutionary conserved RNA-binding protein that plays important roles in neural stem cell maintenance, nervous system development, and tumorigenesis. In glioblastoma, Msi1 is found to be highly expressed and to control a network of cancerrelated genes. In this chapter, we will review the participation of RNA-binding proteins in tumorigenesis and the role of Msi1 in stem cells and in glioblastoma. Furthermore, we will discuss the results of a study done with The Cancer Genome Atlas (TCGA) dataset to map genes highly correlated in expression with Msi1 as an avenue to understand its function in gliomagenesis.
CITATION STYLE
T., D., Sandhu, D., A., J., & O., L. (2011). The Musashi1 RNA-Binding Protein: A Critical Regulator in Glioblastoma. In Molecular Targets of CNS Tumors. InTech. https://doi.org/10.5772/19404
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