Green synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitriles using ZnO nanoparticles prepared with mulberry leaf extract and ZnCl2

Abstract

A highly efficient and environmentally benign protocol for the synthesis of 2-amino-7-hydroxy-4-aryl-4H- chromene-3-carbonitrile derivatives in good to high yields (77%{97%) by one-pot three-component coupling reaction of aromatic aldehydes, malononitrile, and resorcinol under reux condition was developed in aqueous media using ZnO nanoparticles that were prepared in the presence of mulberry leaf extract under mild conditions.