The platelet activating factor receptor: A new anti-infective target in respiratory disease?

25Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

Abstract

There is increasing evidence that vulnerability to pneumococcal pneumonia is mediated by the expression of adhesion receptors for bacteria on lower airway cells. A key bacterial adhesion receptor is the plateletactivating factor receptor (PAFR). In vitro and animal studies have shown that upregulation of PAFR increases vulnerability to infection and blocking PAFR and knockdown of PAFR attenuates infection. Blocking PAFR may therefore be a novel therapeutic strategy in acute and chronic airway infection.

Cite

CITATION STYLE

APA

Grigg, J. (2012). The platelet activating factor receptor: A new anti-infective target in respiratory disease? Thorax, 67(9), 840–841. https://doi.org/10.1136/thoraxjnl-2012-202206

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free