Dysfunctional LAD-1 neutrophils and colitis

Abstract

Leukocyte adhesion deficiency 1 (LAD-1) is characterized by absent or dysfunctional β2 integrin (CD18), leading to defective chemotaxis, adherence, phagocytosis, and bacterial killing. Colitis, except for rare intestinal necrotizing events, is not a well-recognized feature of this immunodeficiency. A case of nonspecific colitis clinically resembling Crohn's disease in a patient with the severe form of LAD-1 (0.5%