In the quest for the discovery of new therapies, the identification of the initial active molecules is a major challenge. Although significant progress in chemistry and biology has been made in recent years, the process remains difficult. In this mini-review, we will explain the major approaches and experimental methods that can be used to identify these molecules. Two main approaches are described, target-based and phenotypic-based and a focus is made on some high throughput technologies and biophysical methods.
CITATION STYLE
Giraud, S. (2024). Identification of first active compounds in drug discovery. how to proceed? Frontiers in Drug Discovery, 4. https://doi.org/10.3389/fddsv.2024.1342866
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