Combinatorial solid-phase synthesis of multivalent cyclic neoglycopeptides

Abstract

Conformationally restricted, multivalent cyclic neoglycopeptides, such as 1, are accessible by a convergent solid-phase synthesis in which an active carbonate is treated with immobilized cyclopeptides bearing free amino side chains. The libraries of glycoclusters obtainable by this procedure are suited for screening for lectin-binding properties.