In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8

Abstract

Background: In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. Methods: FDG-PET was performed in 24 patients and compared to 24 controls. Pearson's correlation was used to analyse correlation. Results: SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8. Conclusion: In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated -although weakly- to CTG-repeat numbers.