Studies on the Sedative Effect of Mitragyna speciosa Korth. as an Endemic Plant in West Borneo, Indonesia

Abstract

Kratom (Mitragyna speciosa Korth.) is an endemic plant of West Borneo (Indonesia). One of its uses in the community is as a sedative. The aim of this research is to determine the effective dose of kratom leaf extract and infusion against male BALB/c mice. The traction test and fireplace test methods were used to determine the sedative effect quantitatively. The qualitative test was carried out by observing the corneal reflex and the body turning reflex. Mice were divided into 5 groups, namely positive control group (diazepam), negative control (CMC 1% + aqua dest), ethanol extract group 12.14 mg/ 20gBB, ethanol extract group 24.29 mg/ 20gBB, ethanol extract group 48.57 mg/ 20gBB, kratom leaf infusion group 39 mg/ 20gBB, kratom leaf infusion group 78 mg/ 20gBB, and kratom leaf infusion group 156 mg/ 20gBB. The results showed that the ethanol extract and infusion of kratom leaf had a sedative effect on male BALB/c mice. The effective doses of ethanolic extract and kratom leaf infusion are 48.57 mg / 20gBB and 156mg / 20g BW, respectively. Kratom leaf ethanolic extract has more potential sedative effect than diazepam as a positive control, whereas kratom leaf infusion is the opposite.