Diverse human tumors obtained directly from surgery or biopsy can grow at high frequency in 3-dimensional Gelfoam® histoculture for long periods of time and still maintain many of their in vivo properties. The in vivo properties maintained in vitro include 3-dimensional growth; maintenance of tissue organization and structure, such as changes associated with oncogenic transformation; retention of differentiated function; tumorigenicity; and growth of multiple types of cells from a single tumor.
CITATION STYLE
Hoffman, R. M., & Freeman, A. E. (2018). In vivo-like growth patterns of multiple types of tumors in Gelfoam® histoculture. In Methods in Molecular Biology (Vol. 1760, pp. 19–28). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7745-1_3
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