Recombination promoted by DNA viruses: Phage λ to herpes simplex virus

49Citations
Citations of this article
127Readers
Mendeley users who have this article in their library.

Abstract

The purpose of this review is to explore recombination strategies in DNA viruses. Homologous recombination is a universal genetic process that plays multiple roles in the biology of all organisms, including viruses. Recombination and DNA replication are interconnected, with recombination being essential for repairing DNA damage and supporting replication of the viral genome. Recombination also creates genetic diversity, and viral recombination mechanisms have important implications for understanding viral origins as well as the dynamic nature of viral-host interactions. Both bacteriophage λ and herpes simplex virus (HSV) display high rates of recombination, both utilizing their own proteins and commandeering cellular proteins to promote recombination reactions. We focus primarily on λ and HSV, as they have proven amenable to both genetic and biochemical analysis and have recently been shown to exhibit some surprising similarities that will guide future studies.

Cite

CITATION STYLE

APA

Weller, S. K., & Sawitzke, J. A. (2014, September 8). Recombination promoted by DNA viruses: Phage λ to herpes simplex virus. Annual Review of Microbiology. Annual Reviews Inc. https://doi.org/10.1146/annurev-micro-091313-103424

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free