The effects of the monoamine oxidase inhibitors (-)deprenyl and (+)-and (-)tranylcypromine on dopamine oxidation in human caudate have been investigated. Oxidation of dopamine has been found to exhibit both (-)deprenyl-sensitive and -insensitive components. The tranylcypromine isomers are both more sensitive towards dopamine than 5-hydroxytryptamine oxidation, (+) isomer being the more effective of the two. These results are discussed in terms of the in vivo action of the drugs and their therapeutic value.
CITATION STYLE
Reynolds, G. P., Riederer, P., & Rausch, W. D. (1980). Dopamine metabolism in human brain: effect of monoamine oxidase inhibition in vitro by (-)deprenyl and (+) and (-) tranylcypromine. Journal of Neural Transmission, Supplement, (16), 173–178. https://doi.org/10.1007/978-3-7091-8582-7_19
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