The effectiveness and tolerability of the topical Symphytum product Traumaplant® (Harras Pharma Curarina, München, Germany) (10% active ingredient of a 2.5:1 aqueous-ethanolic pressed concentrate of freshly harvested, cultivated comfrey herb [Symphytum uplandicum Nyman], corresponding to 25 g of fresh herb per 100 g of cream) in the treatment of patients with myalgia (n=104) were tested against a 1% reference product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n=111 ). The primary efficacy parameter in this double-blind, reference-controlled, randomized, multicenter study of 215 patients with pain in the lower and upper back was pain in motion, assessed with the aid of a visual analogue scale. Secondary efficacy parameters included pain at rest, pain on palpation, and functional impairment. With high concentrations of the treatment product, amelioration of pain on active motion (P<5×10-9), pain at rest (P
CITATION STYLE
Kucera, M., Barna, M., Horácek, O., Kálal, J., Kucera, A., & Hladíkova, M. (2005). Topical Symphytum herb concentrate cream against myalgia: A randomized controlled double-blind clinical study. Advances in Therapy, 22(6), 681–692. https://doi.org/10.1007/BF02849961
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