Olfactory receptors (ORs) form the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date. Homology modeling has become a popular strategy to propose plausible OR models, in order to study the structure-function relationships of the receptors and to aid the discovery and development of ligands capable of modulating receptor activity. In this chapter, we provide a general guideline for OR structure construction, including the collection of candidate templates, structure-based sequence alignment, 3D structure construction, ligand docking, and molecular dynamic simulation.
CITATION STYLE
Wang, X., Stephen Chan, H. C., & Yuan, S. (2023). Modeling of Olfactory Receptors. In Methods in Molecular Biology (Vol. 2627, pp. 183–193). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2974-1_10
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