Synthesis of tetrafluoroethylene-and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

Abstract

Tetrafluoroethylene-containing azides are accessed in two steps (one pot) from tetrafluoroalkyl bromides by metalation and reaction with electrophilic azides. Subsequent copper(i)-catalyzed azide-Alkyne cycloaddition afforded N-Tetrafluoroethyl and N-Tetrafluoroethylene 4-substituted 1,2,3-Triazoles. In addition, the protocol for the synthesis of 4,5-disubstituted 1,2,3-Triazoles is presented.