1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.
CITATION STYLE
Wu, X. H., Liu, G., Zhang, J., Wang, Z. G., Xu, S., Zhang, S. D., … Wang, L. (2004). Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis. Molecular Diversity, 8(2), 165–174. https://doi.org/10.1023/B:MODI.0000025639.89179.60
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