Sesquiterpenos de Ocotea lancifolia (Lauraceae)

Abstract

Six new eremophilane sesquiterpenes, (rel)-4β,5β,7β- eremophil-9-en-12-oic acid (1), (rel)-4β,5β,7β-eremophil-1(10)- en-12-oic acid (2), (rel)-4β,5β,7β-eremophil-1(10)-en-2-oxo-12- oic acid (3), (rel)-4β,5β,7β- eremophil-9-en-12,8α-olide (4), (rel)-4β,5β,7β-eremophil-9-en-12,8β-olide (5) and (rel)-4β,5β,7β-eremophil-9α,10α-epoxy-12-oic acid (6), were isolated from the leaves of a specimen of Ocotea lancifolia (Lauraceae). Two other known sesquiterpenes, 4β,5β,7β- eremophil-11-en- 10α-ol (7) reported for the first time in the genus Ocotea, and the aromadendrene sesquiterpene, spathulenol (8), were also isolated. Their structures were determined on the basis of spectral data (MS, IR, UV and NMR-1D and 2D) and subsequent comparisons with the literature.