Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Abstract

Mixed complexes of Ibuprofen-Pyrimethamine were synthesized using Cd(II) Co(II), Zn(II) and Mn(II). The mixed complexes were characterized based on some physico-chemical and spectroscopic techniques such as infrared, elemental analysis, conductivity measurements, and magnetic moment. Based on the results obtained, the complexes were formulated as [M(L1)(L2)]Cl2 , where M = metal ion, L1 = Pyrimethamine, L2 = Ibuprofen). The complexes were found to be non-electrolytes. The ligands act as bidentate towards the central metal ions with deprotonation occurring at the carboxylic group. The complexes were also analyzed by conductometric titration. Antimicrobial screening against the selected organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus megaterium and Serratia marcescens for the complexes alongside the free ligands was investigated. Antimalarial study was investigated for the compounds against Plasmodium berhei (NK 65 strain). It was observed that the complexes showed significant potentials against the studied organisms.