Subcutaneous murine xenograft models: A critical tool for studying human tumor growth and angiogenesis in vivo

Abstract

Subcutaneous tumor models are widely used in angiogenesis research. Due to the relative simplicity, these mouse models are ideal for the evaluation of molecular hypotheses. In addition, these models are frequently used to assess anti-angiogenic efficacy during drug development. Finally, subcutaneous models can be performed with either xenogeneic or syngeneic tumors, both harboring advantages and drawbacks. Herein, we describe the use of subcutaneous xenograft models in anticancer research.