Effect of hydration states on thermoregulatory responses during exercise in rats

Abstract

Thermoregulatory response during exercise was studied in rats with three hydration states: euhydration, hypohydration (-18% plasma volume by thermal dehydration), and hyperhydration (+24% plasma volume by 5% bovine serum albumin solution infusion). Rats exercised (12.5 m · min-1) for 30 min at an ambient temperature of 25°C. Abdominal temperature (T(ab)) and heart rate were continuously recorded by using a surgically implanted transmitter and telemetry system, and the tail skin temperature (T(ts)) was measured as an index of peripheral vasomotor tone. In the euhydration group, T(ts) showed an increase when Tab reached 37.6°C; an increase of T(ts) was observed at 37.9°C of T(ab) in the hypohydration group and at 37.4°C in the hyperhydration group. The slope of the T(ts)-T(ab) relationship was steeper in the hyperhydration group and less steep in the hypohydration group than in the euhydration group. These results indicate that hypohydration leads to an upward shift in the body temperature threshold for tail vasodilation and an increase in Tab during exercise. Hyperhydration, however, leads to a downward shift of the threshold and the maintenance of a lower T(ab). An elevation of the threshold T(ab) for vasodilation was observed when plasma volume was reduced by more than 20%, and a decrease was observed when plasma volume increased more than 15%.