Evidence of linkage to psychosis on chromosome 5q33-34 in pedigrees ascertained for bipolar disorder

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Abstract

It is hypothesized that the presence of psychotic features may define a subtype of bipolar disorder that is more homogeneous in its genetic predisposition than bipolar disorder as a whole. We used psychosis as an alternative phenotype definition in a re-analysis of the NIMH Bipolar Genetics Initiative data sets. In this analysis we selected only those families in which at least two members were diagnosed with bipolar disorder type 1 with psychotic features. This analysis identified a linkage signal on chromosome 5q33-q34, a region previously implicated in independent linkage studies of schizophrenia and of psychosis, broadly defined. This finding is consistent with the hypothesis that susceptibility to psychosis may characterize at least a subtype of bipolar disorder. © 2006 Wiley-Liss, Inc.

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Kerner, B., Brugman, D. L., & Freimer, N. B. (2007). Evidence of linkage to psychosis on chromosome 5q33-34 in pedigrees ascertained for bipolar disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 144(1), 74–78. https://doi.org/10.1002/ajmg.b.30402

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