Pharmacological modulation of redox status in bone marrow

Abstract

Redox regulation and thiol balance have critical roles in multiple pathways that control myeloproliferation, hematopoietic progenitor cell mobilization, and immune response. Development of redox-modulating anticancer drugs is frequently limited by dose-limiting toxicities including myelosuppression and immunosuppression. This chapter discusses the role of redox status and the equilibrium of free thiol-disulfide couples in the bone marrow niche environment and how certain classes of drugs modulate hematopoiesis and the immune response.