Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells

12Citations
Citations of this article
97Readers
Mendeley users who have this article in their library.

Abstract

Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient’s cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein–protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-κB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here povide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection.

References Powered by Scopus

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

54486Citations
N/AReaders
Get full text

Limma powers differential expression analyses for RNA-sequencing and microarray studies

23941Citations
N/AReaders
Get full text

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

8568Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Ramping Up Antimicrobial Peptides Against Severe Acute Respiratory Syndrome Coronavirus-2

35Citations
N/AReaders
Get full text

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

22Citations
N/AReaders
Get full text

Vitamin D Endocrine System and COVID‐19. Treatment with Calcifediol

22Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

George, B., Amjesh, R., Paul, A. M., Santhoshkumar, T. R., Pillai, M. R., & Kumar, R. (2021). Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-87703-z

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 21

57%

Researcher 10

27%

Professor / Associate Prof. 4

11%

Lecturer / Post doc 2

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 19

56%

Biochemistry, Genetics and Molecular Bi... 7

21%

Nursing and Health Professions 5

15%

Immunology and Microbiology 3

9%

Article Metrics

Tooltip
Mentions
News Mentions: 1
Social Media
Shares, Likes & Comments: 23

Save time finding and organizing research with Mendeley

Sign up for free