The recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean±SD age 55.1±16.7 yrs) and 94 healthy asymptomatic subjects (54.6±7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distention had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti- Helicobacter pylori immunoglobulin G correlated it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis.
CITATION STYLE
Tsang, K. W., Lam, W. K., Kwok, E., Chan, K. N., Hu, W. H. C., Ooi, G. C., … Lam, S. K. (1999). Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis. European Respiratory Journal, 14(6), 1345–1350. https://doi.org/10.1183/09031936.99.14613459
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