Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease

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Abstract

Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coli and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.

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Onderdonk, A. B., Richardson, J. A., Hammer, R. E., & Taurog, J. D. (1998). Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease. Infection and Immunity, 66(12), 6022–6023. https://doi.org/10.1128/iai.66.12.6022-6023.1998

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