MP283ASSOCIATED FACTORS OF PHYSICAL FUNCTION IN LATE CHRONIC KIDNEY DISEASE

Abstract

Introduction and Aims: Chronic kidney disease (CKD) is a global health issue in the world. Accumulating evidence shows that CKD patients are earlier to have impaired physical function than general population. However, the information about associated factors of physical activity is not well-investigated in Taiwan. The aim of this study is to evaluate physical function and its associated factors in CKD patients. Methods: The cross-sectional study enrolled 125 CKD stages 3-5 patients and 67 healthy volunteers (non-CKD). We used body composition monitor to measure fluid, lean tissue index (LTI), and fat tissue index (FTI) status. Physical function was determined by three performance-based tests, including handgrip, 2 minutes step test, and sit-to-stand test within 30seconds. Results: Of all participants, the mean age was 67.6±8.1 yrs in CKD group and 65.9±6.4 yrs in non-CKD group. 55.2% of CKD group and 47.8% of non-CKD group were male. The mean eGFR was 20.5±11.3 ml/min/1.73m2 in CKD group and 90.1±17.1 ml/min/ 1.73m2 in non-CKD group The body mass index (BMI) was higher in CKD group (24.7±3.9kg/m2) than non-CKD group (23.4 ± 3.4 kg/m2) (P=0.032). CKD group had more body fluid than non-CKD group (OH value: 1.0±1.2 v.s. 0.5 ± 0.8, p=0.002). The mean of handgrip, 2 minutes step test, and sit-to-stand test within 30seconds was 26.4 ± 7.8Kg, 101.4±19.6, and 11.0±2.9 respectively in CKD group and 27.9±8.4Kg, 115.3 ±31.8 and 11.7±3.5 respectively in non-CKD group. There was a significant difference of 2 minutes step test between two groups (P<0.01). Multivariate regression revealed that FTI (β=-4.287, 95%CI: -8.133,-0.441, P=0.029) and urine protein-creatinine ratio (β=-10.743, 95%CI: -20.247,-1.238, P=0.027) were negatively and significantly associated with 2 minutes step test in CKD group. Conclusions: Our study demonstrated higher BMI and higher volume status in CKD patients. The performance of physical function was relative poor in CKD patients with higher FTI and higher proteinuria. These findings could provide more information in CKD care program to improve the effect of CKD care.