Magnetic resonance cancer nanotheranostics

Abstract

It is well known that the magnetic spin effects during nanotherapy can cause tumor cell apoptosis and necrosis based on redox reactions. The current study was carried out on C57Bl/6 mice with Lewis lung carcinoma. The magnetic nanocomplex administration combined with the impact of magnetic resonance system (1.5 T) showed maximal antitumor and antimetastatic effects. The electron spin resonance spectra have been used as diagnostic markers and recorded a change in the tumor redox state based on chemical species such as NO-FeS-proteins and ubisemiquinone. The technology of magnetic resonance nanotheranostics could potentially allow to improve the antitumor effect of chemotherapeutic agents in disseminated cancer therapy.